The Scientist

Microarray Data Analysis: Separating the Curd from the Whey

For biologists, DNA microarrays present at once unprecedented opportunities and monumental challenges. In the opportunities column, microarrays produce genome-wide gene expression snapshots, ...
Nanowerk

Microarray Definition: How DNA Microarrays Work, Types, and Uses

Definition: A microarray is a small, flat substrate carrying an ordered grid of microscopic probe features, each containing a known biological molecule, that is used to measure many molecular targets ...
Nature

DNA binding analysis of rare variants in homeodomains reveals homeodomain specificity-determining residues

Homeodomains (HDs) are the second largest class of DNA binding domains (DBDs) among eukaryotic sequence-specific transcription factors (TFs) and are the TF structural class with the largest number of ...
Nature

Diagnostic utility of DNA methylation analysis in genetically unsolved pediatric epilepsies and CHD2 episignature refinement

Sequence-based genetic testing identifies causative variants in ~ 50% of individuals with developmental and epileptic encephalopathies (DEEs). Aberrant changes in DNA methylation are implicated in ...
The Scientist

Making Sense of Microchip Array Data

The overall process begins with cDNA or oligonucleotides spotted in two-dimensional arrays onto glass slides or nylon membranes, or synthesized on biochips using technology borrowed from the ...