In human cells, DNA carries chemical or "epigenetic" marks that decide how genes will be used in different tissues. Yet in a ...

Resistant cells demonstrated global decreases in DNA accessibility with localized opening at resistance-driving loci, indicating non-mutational epigenetic reprogramming rather than canonical oncogenic ...

Cancer cells rapidly adapt to treatments, developing resistance that makes chemotherapy less effective. Researchers used an existing anti-inflammatory drug to disrupt cancer cells’ ability to adapt by ...

In our cells, our DNA carries chemical or 'epigenetic' marks that decide how genes will be used in different tissues. Yet in the group of specialised ...

Aging is accompanied by widespread epigenetic reprogramming, including the loss of heterochromatin and altered chromatin-associated processes. These changes compromise transcriptional precision and ...

This work delineates how Setd2-mediated epigenetic reprogramming overcomes developmental barriers in cloned embryos. Comparative analysis revealed that SCNT embryos exhibit excessive H3K4me3 and ...

In a wholly new approach to cancer treatment, Northwestern University biomedical engineers have doubled the effectiveness of chemotherapy in animal experiments. Instead of attacking cancer directly, ...

The magic cube shows that multi-omics (transcriptome, DNA methylome and chromatin accessibility) form a highly interlinked network and play important but different roles together in cardiac ...